A, C; A',C'-DOUBLY CAPPED β-CYCLODEXTRIN. DIRECT EVIDENCE FOR THE CAPPING STRUCTURE

Article abstract of DOI:10.1016/S0040-4039(01)92908-9

Doubly capped β-cyclodextrin was firstly prepared in good yield by the treatment of β-cyclodextrin with an excess amount (2.6/1 mol/mol) of benzophenone-3,3'-disulfonyl chloride.This successful double capping demonstrates that benzophenone-3,3'-disulfonyl capping takes place on A, C rings.The present double cap is a useful key intermediate for the preparation of regiospecifically tetrasubstituted cyclodextrins.