A practical synthesis of 1,4,7,10-tetraazacyclododecane, a pivotal precursor for MRI contrast agents

Article abstract of DOI:10.1080/00397910008087287

A practical preparation of the versatile macrocycle 1,4,7,10- tetraazacyclododecane (cyclen) was developed starting from cheap and easily available starting materials as ethylenediamine and glyoxal.

Full text of DOI:10.1080/00397910008087287

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Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic
Organic Chemistry
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A Practical Synthesis
of 1,4,7,10-Tetraaza-
Cyclododecane, A Pivotal
Precursor for MRI Contrast
Agents
a
a
Marinella Ferrari , Giovanni B. Giovenzana
,
b
c
Giovanni Palmisano & Massimo Sisti
a
Dipartimento di Chimica Organica e Industriale ,
Facoltà di Scienze MM.FF.NN. , Via Venezian 21,
2
0133, Milano, Italy
b
Dipartimento di Scienze Mediche , Facoltà di
Farmacia , Viale Ferrucci 33, 28100, Novara, Italy
c
Dipartimento di Scienze Chimiche, Fisiche e
Matematiche , Facoltà di Scienze MM.FF.NN. , Via
Lucini 3, 22100, Como, Italy Fax: E-mail:
Published online: 04 Dec 2007.
To cite this article: Marinella Ferrari , Giovanni B. Giovenzana , Giovanni Palmisano
&
Massimo Sisti (2000) A Practical Synthesis of 1,4,7,10-Tetraaza-Cyclododecane, A
Pivotal Precursor for MRI Contrast Agents, Synthetic Communications: An International
Journal for Rapid Communication of Synthetic Organic Chemistry, 30:1, 15-21, DOI:
10.1080/00397910008087287
To link to this article: http://dx.doi.org/10.1080/00397910008087287

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