Synthesis of aminobisphosphonate

Article abstract of DOI:10.1080/00397919608003560

A new facile synthesis of aminobisphosphonate was reported. Dibenzylamine bisphosphonate (1) is prepared from dibenzylamine, triethyl orthoformate and diethyl phosphite. Deprotection by hydrogen transfer reaction and acid hydrolysis afforded aminobisphosphonate (2).

Full text of DOI:10.1080/00397919608003560

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Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic
Organic Chemistry
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Synthesis of
Aminobisphosphonate
Darko Kantoci a , J. Kane Denike a & William J.
Wechter a
a Loma Linda University, Laboratory of Chemical
Endocrinology, Loma Linda, CA, 92350
Available online: 21 Aug 2006
To cite this article: Darko Kantoci, J. Kane Denike & William J. Wechter (1996):
Synthesis of Aminobisphosphonate, Synthetic Communications: An International
Journal for Rapid Communication of Synthetic Organic Chemistry, 26:10, 2037-2043
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