Synthesis of (E)-9,10,13-trihydroxy-11-octadecanoic acids

Article abstract of DOI:10.1246/bcsj.67.839

Our previous research concerning anti-rice blast fungus substances from the rice plants has led to the isolation of various types of oxygenated fatty acids as exemplified by 9,12,13-trihydroxy C-18 fatty acid. The fatty acids play an important role in the defense of the rice plants against this fungus. For evaluation of biological activity, we needed the isomeric trihydroxy fatty acids. This paper describes the synthesis of four stereoisomers of 9,10,13-trihydroxy fatty acid.