AN EFFICIENT SYNTHESIS OF JOLKINOLIDE E INVOLVING THE BUTENOLIDE RING FORMATION

Article abstract of DOI:10.1246/cl.1982.1689

A synthesis of jolkinolide E from the bicyclic enone 3 using intramolecular Wittig reaction is described.In this synthesis a facile esterification method by means of a mixed anhydride of trichloroacetic acid catalized by DMAP, which culminates in the effective synthesis of the α,β,γ-trisubstituted butenolide ring, is also described.