Soft Matter p. 2521 - 2529 (2011)
Update date:2022-08-29
Topics:
Yin, Yanzhen
Wang, Liang
Jin, Haiyan
Lv, Chunyan
Yu, Shuangjiang
Huang, Xin
Luo, Quan
Xu, Jiayun
Liu, Junqiu
To construct a smart artificial antioxidative enzyme on a nano-scaffold, a novel method for designing glutathione peroxidase (GPx) active sites on block copolymer vesicles was developed by simple blending predesigned temperature-sensitive block copolymers with the main catalytic units of GPx. A series of functional block copolymers, poly(N-isopropylacrylamide)-b- polyacrylamides loaded with recognition and catalytic sites, were synthesized via ATRP and click chemistry. Through altering the molar ratio of the functional copolymers, the optimum GPx mimic based on copolymer vesicles was obtained by self-assembly of temperature-sensitive block copolymers through a blending process. Significantly, the catalytic activity of the optimum GPx mimic can be well modulated by changing the temperature. It was proved that the change in self-assembly structure of the block copolymer played an important role in the modulation of the catalytic activity. This method not only bodes well for designing smart antioxidative enzyme mimics that could be used in cosmetics as antioxidative additives but also highlights the construction of other regulatory biologically related functional biomaterials.
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