Syntheses of [21-11C] and (21-13C)progesterone

Article abstract of DOI:10.1002/(SICI)1099-1344(199708)39:8<695::AID-JLCR10>3.0.CO;2-4

[21-¹¹C]Progesterone was synthesised via the cross-coupling 17β-carboxylic acid chloride-4-androsten-3-one with lithium [¹¹C]methyl(2-thienyl)cuprate (LiCN). The title compound was obtained in 30-35% decay corrected radiochemical yield, based on [¹¹C]methyl iodide, within 35 minutes after end of radionuclide production. The specific radioactivity was 14 GBq/μmole. (21-¹³C)Progesterone was synthesised using the same procedure for determination of the position of the label.