THE ABSOLUTE CONFIGURATIONS OF (+)-THALICTRIFOLINE AND (+)-CORYDALIC ACID METHYL ESTER. TOTAL SYNTHESIS OF (+)-THALICTRIFOLINE.

Article abstract of DOI:10.1016/S0040-4039(01)82899-9

(+)-Thalictrifoline (3) has been synthesized from an optically resolved (+)-8-oxo-13-carboxytetrahydroprotoberberine (13) whose absolute configuration was established by correlation with (+)-18.This determines the absolute configurations of (+)-thalictrifoline (3) as 13R, 14R and (+)-corydalic acid methyl ester (9) as 3R, 4R.