Straightforward synthesis of 1-(2,3-dideoxy-β-D-glycero-pent-2- enofuranosyl)-thymine

DOI: 10.1080/15257779408011874

Source and publish data:

Nucleosides and Nucleotides p. 1011 - 1013 (1994)

Update date:2022-08-28

Topics:

Authors:

Negron Negron

Islas Islas

Diaz Diaz

Cruz Cruz

Quiclet-Sire

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Article abstract of DOI:10.1080/15257779408011874

A two steps synthesis of the antiviral drug (d4T) 3 from thymidine 1 is proposed, which implies a concomitant deprotection-elimination process by action of t-BuOK in DMF on 5'-O-t-butyldimethylsylil-3'-O-methanesulfonyl- thymidine 2.

Full text of DOI:10.1080/15257779408011874

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