Straightforward synthesis of 1-(2,3-dideoxy-β-D-glycero-pent-2- enofuranosyl)-thymine

Article abstract of DOI:10.1080/15257779408011874

A two steps synthesis of the antiviral drug (d4T) 3 from thymidine 1 is proposed, which implies a concomitant deprotection-elimination process by action of t-BuOK in DMF on 5'-O-t-butyldimethylsylil-3'-O-methanesulfonyl- thymidine 2.