Chemistry - A European Journal
10.1002/chem.202002442
COMMUNICATION
Table 2.: MIC in mg/L of compounds 2a-c, rac-4 and 3a-c against Gram-positive
MSSA and MRSA clinical isolates. Tetracycline and vancomycin were used as
references.
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2a
4
4
4
4
Diorcinol D 2b
Diorcinol I 2c
Diorcinol J 4
8
8
4
8
8
8
8
8
>64
>64
>64
>64
3a
3b
3c
-
-
-
-
-
-
-
-
-
-
-
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2368–2375; l) P. Zhang, X. Li, X.-L- Yuan, Y.-M. Du, B.-G. Wang, Z.-F.
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We herein report the first syntheses of the natural products
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overall yields (51% (2b), 20% (2c), 16% (4)). Furthermore,
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4
originally assigned to structure 2a is actually diorcinol D 2b. In
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2
1
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c and their synthetic isomer 2a showed significant inhibition of
4
2
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Acknowledgements
We thank the Fonds der Chemischen Industrie (FCI) for generous
financial support. G.J.B. thanks the Universität Hamburg for a
PhD fellowship (Hamburg Stipendium). W.R.S and M.G. thank the
Rahn-Quade foundation for funding. Furthermore, we thank I.
Nevoigt for technical support.
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doi: 10.3389/fmicb.2018.00806
Keywords: MRSA • Total Synthesis • Natural Products • Biofilm
•
Structure Elucidation
4
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