Catalytic single-chain antibodies possessing β-lactamase activity selected from a phage displayed combinatorial library using a mechanism-based inhibitor

DOI: 10.1016/S0040-4039(99)01695-0

Source and publish data:

Tetrahedron Letters p. 8063 - 8066 (1999)

Update date:2022-08-11

Topics:

Authors:

Tanaka, Fujie

Almer, Helena

Lerner, Richard A.

Barbas III, Carlos F.

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Article abstract of DOI:10.1016/S0040-4039(99)01695-0

Catalytic single-chain antibodies (scFvs) possessing β-lactamase activity were selected from a phage displayed combinatorial antibody library using a penam sulfone mechanism-based inhibitor of β-lactamase. The scFvs FT6 and FT12 catalyzed the hydrolysis o

Full text of DOI:10.1016/S0040-4039(99)01695-0

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