Discovery and Optimization of a Porcupine Inhibitor

DOI: 10.1021/acs.jmedchem.5b00507

Source and publish data:

Journal of Medicinal Chemistry p. 5889 - 5899 (2015)

Update date:2022-08-11

Topics:

Authors:

Duraiswamy, Athisayamani Jeyaraj

Lee, May Ann

Madan, Babita

Ang, Shi Hua

Tan, Eldwin Sum Wai

Cheong, Wei Wen Vivien

Ke, Zhiyuan

Pendharkar, Vishal

Ding, Li Jun

Chew, Yun Shan

Manoharan, Vithya

Sangthongpitag, Kanda

Alam, Jenefer

Poulsen, Anders

Ho, Soo Yei

Virshup, David M.

Keller, Thomas H.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/acs.jmedchem.5b00507

Wnt proteins regulate various cellular functions and serve distinct roles in normal development throughout life. Wnt signaling is dysregulated in various diseases including cancers. Porcupine (PORCN) is a membrane-bound O-acyltransferase that palmitoleate

Full text of DOI:10.1021/acs.jmedchem.5b00507

Products guided by the article

Product name:N-1,1''-BIPHENYL-4-YL-2-CHLOROACETAMIDE

Cas No:3289-77-8

R&D Labs maybe for 3289-77-8

Zhejiang Rongkai Chemical Technology Co.,Ltd.

Contact:+86-578-8185786

Address:Shangjiang Industrial Zone,Suichang
Changzhou Ansciep Chemical Co.,Ltd.

Contact:+86 519 8630 5871

Address:A-710 Boan International, 8 East Guangdian Road,Wujin,Changzhou
Taizhou YOJOY Chemical Co., Ltd.

Contact:13857143241

Address:Yangfu Industrial Park, Xianju, Zhejiang, P. R. China
Suzhou CarbonWell Pharma-Tech Co., Ltd

Contact:Tel: + 86 (0)512-8898-1216; + 86-18606258602

Address:2358 Changan Road, Wujiang Scientific Innovation Park, Wujiang, Jiangsu Province, P. R. China 215200
Qingdao Kylin Trading Co., Ltd.

Contact:0086-532-68979884/58972912/68972263/65/88171519

Address:Room 2308,A building International Trade Center No.230 Changjiang Middle Road of Qingdao Economic Development Zone,Shandong,China.

Relevant to this article

Regioselectivity of reactions of vinyl- and isopropenylcyclopentadienide anions with electrophilic agents. Synthesis and crystal structures of complexes [C₅H₄C(Me)=CH₂]ZrCl₃·2THF and [C₅Me₄CH=CH₂]ZrCl₃·2THF

Doi:10.1007/s11172-005-0263-y
(2005)
6-Arylimino-2-(2-(1-phenylethyl)naphthalen-1-yl)-iminopyridylmetal (Fe and Co) complexes as highly active precatalysts for ethylene polymerization: Influence of metal and/or substituents on the active, thermostable performance of their complexes and resul

Doi:10.3390/molecules25184244
(2020)
Highly Efficient Conversion of Renewable Levulinic Acid to?n-Butyl Levulinate Catalyzed by Sulfonated Magnetic Titanium Dioxide Nanotubes

Doi:10.1007/s10562-020-03177-0
(2020)
Doi:10.1021/ja01311a009
(1935)
A new facile synthesis of a thromboxane B₂ precursor

Doi:10.1080/00397919508011758
(1995)
SUBSTITUENT EFFECTS FOR THE BF3-MEDIATED REACTIONS OF ALLYLTRIBUTYLTIN AND ALLYLTRIETHYLLEAD WITH BENZALDEHYDE

Doi:10.1002/poc.610080108
(1995)

Article Doi