Isolation of a major metabolite (i-OHAP) of aprindine and its identification as N-[3-(N,N-diethylamino)propyl]-N-phenyl-2-aminoindan-5-ol

DOI: 10.1248/bpb.21.530

Source and publish data:

Biological and Pharmaceutical Bulletin p. 530 - 534 (1998)

Update date:2022-08-11

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Authors:

Shimizu, Mikiko

Takatori, Kazuhiko

Kajiwara, Masahiro

Ogata, Hiroyasu

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Article abstract of DOI:10.1248/bpb.21.530

i-OHAP, a major metabolite of aprindine (AP), was isolated by TLC from rat feces and identified as N-13-(N,N-diethylamino)propyl]-N-phenyl-2- aminoindan-5-ol, based on ¹H-NMR, the H-H correlation spectroscopy (COSY) spectrum, MS and LC-MS. Its

Full text of DOI:10.1248/bpb.21.530

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