Journal of Organic Chemistry p. 2965 - 2975 (1991)
Update date:2022-08-16
Topics:
Keifer, Paul A.
Schwartz, Robert E.
Koker, Moustapha E. S.
Hughes, Robert G.
Rittschof, Dan
Rinehart, Kenneth L.
Biologically active extracts of the Carribean sponge Agelas conifera have yielded, in exhaustive studies, the diacetate salts of seven new bromopyrroles (1, 3-8), as well as that of the known debromooroidin dimer sceptrin (2).These compounds were found to be antiviral and antibacterial and were active in barnacle settlement and biochemical prophage induction assays.The structures assigned were based on spectroscopic comparison to sceptrin and two-dimensional NMR data.Synthetic bromopyrroles were used to verify bromine substitution patterns.The oxysceptrins (4, 5) are characterized by their aminoimidazolinone group, the ageliferins (6-8) by a unique cyclohexene-based skeleton.
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