Synthesis and utilization of 13C(8)-enriched purines.

Article abstract of DOI:10.1080/07328319908045591

A new and more efficient method is presented for the synthesis of 13C(8)-enriched adenine. In addition, we present for the first time the synthesis of 13C(8)-enriched 2-aminopurine and purine. All three analogues have been converted to the corresponding ribonucleosides. The adenine analogue has been further converted to the 2'-deoxy-nucleoside and incorporated into a synthetic oligonucleotide. Data is presented demonstrating the utility of 13C-enrichment in heteronuclear isotope-edited NMR spectra.

Full text of DOI:10.1080/07328319908045591

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Nucleosides and Nucleotides
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Synthesis and Utilization of 13C(8)-
Enriched Purines
Christopher J. Lafrancois a , June Fujimoto a & Lawrence C. Sowers a
a Division of Pediatrics , City of Hope National Medical Center
Duarte , CA, 91010
Published online: 04 Oct 2006.
To cite this article: Christopher J. Lafrancois , June Fujimoto & Lawrence C. Sowers (1999)
Synthesis and Utilization of 13C(8)-Enriched Purines, Nucleosides and Nucleotides, 18:1, 23-37, DOI:
10.1080/07328319908045591
To link to this article: http://dx.doi.org/10.1080/07328319908045591
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