Homogeneous isomerization of 1,2-dicarbethoxy-1,2,3,6-tetrahydropyridazine by ruthenium complexes

Article abstract of DOI:10.1016/0022-328X(88)87047-5

N-protected 1,2,3,4-tetrahydropyridazines are readily obtained from the corresponding 1,2,3,6-tetrahydro-derivatives by double bond migration induced by ruthenium complexes.Almost quantitative conversions and complete chemioselectivities are achieved using RuCl2(PPh3)4 as catalyst precursor at 100 deg C in a pressure vessel.In the same conditions the cluster complex H4Ru4(CO)12 shows lower activity, while HRh(PPh3)4 gives unsatisfactory results.