Reaction of Benzocyclobutenoxides with Nitriles: Synthesis of Hypecumine and Other 3-Substituted Isoquinolines

DOI: 10.1016/0040-4039(94)88462-5

Source and publish data:

Tetrahedron Letters p. 9191 - 9194 (1994)

Update date:2022-08-11

Topics:

Authors:

Fitzgerald, John J.

Michael, Forrest E.

Olofson, R. A.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0040-4039(94)88462-5

Treatment of benzocyclobuten-2-ols with MeLi affords o-tolualdehyde anions which in the presence of nitriles cyclize to 3-substituted isoquinolines.Examples include the synthesis of the alkaloid hypecumine from the precursors, 14 and 19 (1:1), in 50percen

Full text of DOI:10.1016/0040-4039(94)88462-5

Products guided by the article

Product name:3-PHENYLISOQUINOLINE

Cas No:37993-76-3

R&D Labs maybe for 37993-76-3

zhangjiagang bonded areas banggao co;ltd

website:http://www.shunchangchem.com

Contact:0086-13921972933

Address:Dongsha Chemical Zone.Zhangjiagang, Jiangsu Province
Wuhan Soleado Technology Co.,Ltd.

Contact:86-2783341481 18971291927

Address:RM2405 Unit 1 Builing 1, Taiyin Tower, Changqing Road,Wuhan China
Taizhou KEDE Chemical.Co.,Ltd.

Contact:86-576-84613060

Address:Jiangkou Chemical Zoon
Nanjing Chemipioneer Pharma&Tech Co.,Ltd

website:http://www.chemipioneer.com.cn

Contact:+86-25-52685700

Address:Room 305，A Block，Biological-Medicine Building，Business Start-up Center，Xin-ke 1st Road, High-tech development zone，Nanjing city，Jiangsu Province, China
Hangzhou yi lu biont technology Co., LTD

Contact:+86-571-88152630

Address:Hangzhoushi HuafengRoad Yicheng3Building1001room.

Relevant to this article

Doi:10.1007/BF00930044
()
Synthetic Cathinone Analogues Structurally Related to the Central Stimulant Methylphenidate as Dopamine Reuptake Inhibitors

Doi:10.1021/acschemneuro.9b00284
(2019)
Discovery of a novel class anti-proliferative agents and potential inhibitors of EGFR tyrosine kinases based on 4-anilinotetrahydropyrido[4,3-d]pyrimidine scaffold: Design, synthesis and biological evaluations

Doi:10.1016/j.bmc.2015.05.059
(2015)
Pd-catalyzed reduction of aryl halides using dimethylformamide as the hydride source

Doi:10.1016/j.tetlet.2007.07.077
(2007)
Rearomatization of trifluoromethyl sulfonyl dihydropyridines: Thermolysis vs photolysis

Doi:10.1002/poc.3789
(2017)
Hydrolysis of 3-carboxy-6,8-difluoro-7-hydroxycoumarin (Pacific Blue) succinimidyl ester under acidic and basic conditions

Doi:10.1016/j.dyepig.2012.08.005
(2013)

Article Doi