Reaction of Benzocyclobutenoxides with Nitriles: Synthesis of Hypecumine and Other 3-Substituted Isoquinolines

DOI: 10.1016/0040-4039(94)88462-5

Source and publish data:

Tetrahedron Letters p. 9191 - 9194 (1994)

Update date:2022-08-11

Topics:

Authors:

Fitzgerald, John J.

Michael, Forrest E.

Olofson, R. A.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0040-4039(94)88462-5

Treatment of benzocyclobuten-2-ols with MeLi affords o-tolualdehyde anions which in the presence of nitriles cyclize to 3-substituted isoquinolines.Examples include the synthesis of the alkaloid hypecumine from the precursors, 14 and 19 (1:1), in 50percen

Full text of DOI:10.1016/0040-4039(94)88462-5

Products guided by the article

Product name:3-PHENYLISOQUINOLINE

Cas No:37993-76-3

R&D Labs maybe for 37993-76-3

ANHUI CHEM-BRIGHT BIOENGINEERING CO.,LTD

Contact:86-561-4080321

Address:No.8 Lieshan Industrial Zone of Huaibei
Anhui Jiatiansen Agrochemical Co.,Ltd

Contact:15366811918

Address:chemical industrial park,xiangyu town,dongzhi county,anhui,china
Wuxi Highness Chemical Co.,Ltd

website:https://www.phtpharmatech.com/

Contact:86-510-81771080

Address:No58 East Xinguan Rd, Guanlin Town, Yixing City, Jiangsu China
Jiangsu Institute of Ecomones Co., Ltd

website:http://www.jsmone.com

Contact:+86-519-82821700

Address:95 Huanyuan N. Road, Jintan, Jiangsu, China
CHEM PLUS

Contact:0027-717-456976

Address:2ND FLOOR, 325 VAUSE ROAD, OVERPORT, 4001, SOUTH AFRICA

Relevant to this article

Doi:10.1007/BF00930044
()
Synthetic Cathinone Analogues Structurally Related to the Central Stimulant Methylphenidate as Dopamine Reuptake Inhibitors

Doi:10.1021/acschemneuro.9b00284
(2019)
Discovery of a novel class anti-proliferative agents and potential inhibitors of EGFR tyrosine kinases based on 4-anilinotetrahydropyrido[4,3-d]pyrimidine scaffold: Design, synthesis and biological evaluations

Doi:10.1016/j.bmc.2015.05.059
(2015)
Pd-catalyzed reduction of aryl halides using dimethylformamide as the hydride source

Doi:10.1016/j.tetlet.2007.07.077
(2007)
Rearomatization of trifluoromethyl sulfonyl dihydropyridines: Thermolysis vs photolysis

Doi:10.1002/poc.3789
(2017)
Hydrolysis of 3-carboxy-6,8-difluoro-7-hydroxycoumarin (Pacific Blue) succinimidyl ester under acidic and basic conditions

Doi:10.1016/j.dyepig.2012.08.005
(2013)

Article Doi