Microbiological transformations 37. An enantioconvergent synthesis of the β-blocker (R)-Nifenalol using a combined chemoenzymatic approach

Article abstract of DOI:10.1016/S0040-4020(97)00639-X

This work describes the synthesis of (R)-Nifenalol based on an enantioconvergent chemoenzymatic hydrolysis of para-nitrostyrene oxide. A mathematical approach is devised which allowed to optimize the process.