The Involvement of an O2-Derived Nucleophilic Species in Acyl-Carbon Cleavage, Catalysed by Cytochrome P-45017α: Implications for Related P-450 Catalysed Fragmentation Reactions

DOI: 10.1039/c39940001501

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 1501 - 1504 (1994)

Update date:2022-08-29

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Authors:

Robichaud, Peter

Wright, J. Neville

Akhtar, Muhammad

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Article abstract of DOI:10.1039/c39940001501

The postulated iron peroxy species involved in acyl-carbon fission by 17α-hydroxylase-17,20-lyase (P-450_17α) was trapped by an aldehyde analogue, partial 9, that was cleaved by the enzyme 10 times faster than the side-chain of the natural substrate 1.

Full text of DOI:10.1039/c39940001501

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