
Journal fur Praktische Chemie - Chemiker-Zeitung p. 17 - 22 (1993)
Update date:2022-08-29
Topics:
Stanetty, Peter
Rodler, Inge
Krumpak, Barbara
The nitrophthalides 3a-d aimed as intermediates in the synthesis of the title compounds 6a-d were obtained via regioselective reduction of 3-nitrophthalic anhydride 1 or by nitration of phthalide and 3,3-dimethylphthalide, respectively.Reductive methylation of the nitro groups afforded the dimethylaminophthalides 5a-d which in turn were reacted with MeMgI or in the case of 5d reduced by LiAlH4 leading finally to the title compounds.
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