Alkylcobalamins: formation by enantioselective alkylation of cob(I)alamin, 1H NMR spectra, and conformational analysis of the alkyl group

Article abstract of DOI:10.1016/0022-328X(92)83446-O

The 1H NMR spectra of a series of alkylcobalamins, principally 2-oxy substituted, including adenosyl- and ribosylcobalamin, have been analysed with particular attention to the conformation of the alkyl moiety.The enantioselectivity of formation of some of these compounds from their chiral precursors has been determined (NMR analysis) and rationalized.