Bioorganic and Medicinal Chemistry Letters p. 350 - 353 (2007)
Update date:2022-08-11
Topics:
Petrocchi, Alessia
Koch, Uwe
Matassa, Victor G.
Pacini, Barbara
Stillmock, Kara A.
Summa, Vincenzo
4,5-Dihyroxypyrimidine carboxamides, which evolved from a related series of HCV NS5b polymerase inhibitors, have been optimized to provide selective HIV integrase strand transfer inhibitors. Extensive SAR around the benzylamide moiety led to the identification of the p-fluorobenzylamide as optimal in the enzymatic assay.
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Doi:10.1021/acs.jmedchem.5b01355
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