Facile synthesis of 1,4-dihydropyridine monocarboxylic acids and unsymmetric dicarboxylates via quaternary ammonium salts of 2-aminoethyl 1,4-dihydropyridine-3,5-dicarboxylates

Article abstract of DOI:10.1080/00397919708005632

Useful 1,4-dihydropyridine unsymmetric dicarboxylates [nitrendipine (1), nicardipine (2)] and monocarboxylic acid 4 were prepared from unsymmetric 2-aminoethyl methyl 1,4-dihydropyridine-3,5-dicarboxylates 2 and 3 via their corresponding quaternary ammonium salts 5-9.

Full text of DOI:10.1080/00397919708005632

This article was downloaded by: [Columbia University]
On: 11 November 2014, At: 01:59
Publisher: Taylor & Francis
Informa Ltd Registered in England and Wales Registered Number: 1072954
Registered office: Mortimer House, 37-41 Mortimer Street, London W1T 3JH,
UK
Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic
Organic Chemistry
Publication details, including instructions for
authors and subscription information:
http://www.tandfonline.com/loi/lsyc20
Facile Synthesis of
1,4-Dihydropyridine
Monocarboxylic Acids and
Unsymmetric Dicarboxylates
via Quaternary Ammonium
Salts of 2-Aminoethyl
1,4-Dihydropyridine-3,5-
dicarboxylates
Masahiko Kinugawa a & Takehiro Ogasa a
a Sakai Research Laboratories , Kyowa Hakko Kogyo
Co., Ltd. , 1-1-53, Takasu-cho, Sakai, Osaka, 590,
Japan
Published online: 22 Aug 2006.
To cite this article: Masahiko Kinugawa & Takehiro Ogasa (1997) Facile Synthesis
of 1,4-Dihydropyridine Monocarboxylic Acids and Unsymmetric Dicarboxylates via
Quaternary Ammonium Salts of 2-Aminoethyl 1,4-Dihydropyridine-3,5-dicarboxylates,
Synthetic Communications: An International Journal for Rapid Communication of
Synthetic Organic Chemistry, 27:19, 3321-3331, DOI: 10.1080/00397919708005632
To link to this article: http://dx.doi.org/10.1080/00397919708005632
PLEASE SCROLL DOWN FOR ARTICLE

Taylor & Francis makes every effort to ensure the accuracy of all the
information (the “Content”) contained in the publications on our platform.
However, Taylor & Francis, our agents, and our licensors make no
representations or warranties whatsoever as to the accuracy, completeness,
or suitability for any purpose of the Content. Any opinions and views
expressed in this publication are the opinions and views of the authors, and
are not the views of or endorsed by Taylor & Francis. The accuracy of the
Content should not be relied upon and should be independently verified with
primary sources of information. Taylor and Francis shall not be liable for any
losses, actions, claims, proceedings, demands, costs, expenses, damages,
and other liabilities whatsoever or howsoever caused arising directly or
indirectly in connection with, in relation to or arising out of the use of the
Content.
This article may be used for research, teaching, and private study purposes.
Any substantial or systematic reproduction, redistribution, reselling, loan,
sub-licensing, systematic supply, or distribution in any form to anyone is
expressly forbidden. Terms & Conditions of access and use can be found at
http://www.tandfonline.com/page/terms-and-conditions