Optically Active Trifluoromethylcarbinols as Chiral Solvating Agents for Asymmetric Transformations at a Ring-Nitrogen Atom. Synthesis of Optically Active N-Chloroaziridines and Stereochemical Aspects of Chiral Solvent-Aziridine Solute Complexes

Article abstract of DOI:10.1021/jo00164a002

Chlorination at a ring nitrogen of an aziridine substrate, when carried out with tert-butyl hypochlorite or N-chlorosuccinimide in the presence of chiral trifluoromethylcarbinols, affords optically active N-chloroaziridines.Synthesis of chiral N-chloroazi