Phospholipase C inhibitors: A new class of cytotoxic agents

DOI: 10.1021/jm00040a016

Source and publish data:

Journal of Medicinal Chemistry p. 2232 - 2237 (1994)

Update date:2022-08-30

Topics:

Authors:

Perrella

Chen Chen

Behrens Behrens

Kaltenbach III

Seitz Seitz

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Article abstract of DOI:10.1021/jm00040a016

A series of nitrocoumarin and nitrochromene derivatives have been prepared and shown to inhibit the phosphatidylinositol-specific phospholipase C(PLC)(IC₅₀ < 10 μg/mL) isolated from human melanoma. The inhibition of PLC by nitrocoumarin 4a was

Full text of DOI:10.1021/jm00040a016

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