Synthesis of some fluorinated acids, ketones and alcohols derived from 3,3,3-trifluoropropionic acid

Article abstract of DOI:10.1016/S0022-1139(97)00068-7

The stereoselective synthesis of 3-fluoro-2-alkenoic acids was achieved by the reaction of lithium 3,3,3-trifluoropropionate with Grignard reagents. 2,2,2-Trifluoroethyl alkyl ketones were prepared by the reaction of 3,3,3-trifluoropropionic acid chloride with either lithium dialkylcuprates or magnesium dialkylcuprates. Optically active 1,1,1-trifluoro-3-alkanols were obtained by the enzymatic hydrolysis of the corresponding acetates.