
Journal of the Chemical Society. Chemical communications p. 1379 - 1380 (1994)
Update date:2022-08-11
Topics:
Klinge, Michael
Cheng, Hengmiao
Zabriskie, T. Mark
Vederas, John C.
A series of N-formyl amides were synthesized by condensation of N,N-bis(trimethylsilyl)formamide with acid chlorides (59-90percent yields), or by reaction of hydroxyglycyl peptides with 90percent hydrogen peroxide (45percent yield); a number of N-formyl amides which bear a phenyl substituent are mechanism-based irreversible inactivators of peptidylglycine α-hydroxylating monooxygenases purified from pig pituitary and from honeybee heads.
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