Irreversible Inhibition of Mammalian and Insect Peptidylglycine &α-Hydroxylating Monooxygenases (PHMs), Peptide Amidating Enzymes, by N-Formyl Amides

Article abstract of DOI:10.1039/c39940001379

A series of N-formyl amides were synthesized by condensation of N,N-bis(trimethylsilyl)formamide with acid chlorides (59-90percent yields), or by reaction of hydroxyglycyl peptides with 90percent hydrogen peroxide (45percent yield); a number of N-formyl amides which bear a phenyl substituent are mechanism-based irreversible inactivators of peptidylglycine α-hydroxylating monooxygenases purified from pig pituitary and from honeybee heads.

Full text of DOI:10.1039/c39940001379

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