Approaches to the Synthesis of Cytochalasans. Part 3. Synthesis of a Substituted Tetrahydroisoindolinone Moiety Possessing the Same Relative Configuration as Proxiphomin

Article abstract of DOI:10.1002/hlca.19810640125

The total synthesis of the tetrahydroisoindolinone moiety corresponding to proxiphomin (1) is described, bearing functional groups for the attachment of the macrocyclic ring.Knoevenagel-Cope condensation of racemic 2-(benzyloxycarbonylamino)-3-phenylpropa