Alkaloids and other compounds from seeds of Tabernaemontana cymosa

Article abstract of DOI:10.1016/S0031-9422(96)00645-0

From the seeds of Tabernaemontana cymosa (= T. psychotrifolia) 17 indole alkaloids and six lignan glacosides were isolated, besides triacylglycerols, 9,12-octadecadienoic acid, lupeol, (+)-lyoniresinol, obtusifoliol, sweroside and a glucoside of 3-O-methylgallic acid. 9-(β-D-Glucopyranosyloxy)- tetrahydroalstonine, (+)-5,5'-dimethoxy-9-O-(β-D- glucopyranosyl)lariciresinol, (-)-2α-O-(β-D-glucopyranosyl)-lyoniresinol and 3-O-(β-D-glucopyranosyl)-5-O-methylgallic acid are described for the first time. Structural determination is based on spectroscopic studies and/or on comparison with authentic compounds. Some of the isolated substances exhibited significant antifungal and/or cytotoxic effects.