Adverse effects of alkali and acid on the anticoagulant potency of heparin, evaluated with methyl 2-deoxy-2-sulfamino-α-D-glucopyranoside 3-sulfate as a model compound

Article abstract of DOI:10.1016/S0008-6215(00)90546-9

A variety of chemical modifications can induce a reduction in the anticoagulant activity of heparin.Among such modifications are the removal in alkaline solution of the 2-O-sulfonate group of α-L-idopyranosyluronic acid 2-sulfate residues (1) and, in a we