4(1H)-quinolinone alkaloids an efficient synthesis of graveoline by palladium-catalysed reductive N-heterocyclisation

Article abstract of DOI:10.1080/00397919608003640

An efficient synthesis of the 4H-quinolone alkaloid graveoline has been achieved by a route featuring an Pd(II)-catalysed reductive N-heterocyclisatton [ CO(3 MPa), Pd(TMB)₂, TMPhen, 170 °C, 3h] of 2′-nitrochalcone as a key step.

Full text of DOI:10.1080/00397919608003640

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4(1H)-Quinolinone Alkaloids.
An Efficient Synthesis of
Graveoline by Palladium-
Catalysed Reductive N-
Heterocyclisation
R. Annunziata a , S. Cenini b , G. Palmisano c
S. Tollari b
&
a Dipartimento di Chimica Organica ed
Industriale, Via Venezian 21, Milano, 20133,
Italy
b Dipartimento di Chimica Inorganica,
Metallorganica e Analitica and CNR Center, Via
Venezian 21, Milano, 20133, Italy
c Dipartimento di Scienza e Tecnologia del
Farmaco, Via Giuria 9, Torino, 10125, Italy
Published online: 21 Aug 2006.
To cite this article: R. Annunziata , S. Cenini , G. Palmisano & S. Tollari (1996)
4(1H)-Quinolinone Alkaloids. An Efficient Synthesis of Graveoline by Palladium-
Catalysed Reductive N-Heterocyclisation, Synthetic Communications: An
International Journal for Rapid Communication of Synthetic Organic Chemistry,
26:3, 495-501, DOI: 10.1080/00397919608003640
To link to this article: http://dx.doi.org/10.1080/00397919608003640

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