Indium hydride catalyzed chemo- and diastereoselective reductive aldol reactions

Article abstract of DOI:10.1016/j.jorganchem.2013.07.083

The reductive aldol reaction of enones has been established catalyzed by Br₂InOMe (cat.)-MePhSiH₂ system where Br₂InH acted as an active catalytic species. Addition of 1.0 equivalent of MeOH was essential for catalytic turnover. The system, Br₂InOMe(cat.)- MePhSiH₂-MeOH, provided highly chemoand diastereoselective reductive aldol reaction of enones with functionalized substrates such as α-bromo carbonyls, α-keto esters and α-alkoxy ketones.