Chemistry Letters p. 295 - 296 (1998)
Update date:2022-08-11
Topics:
Torimura, Masaki
Yoshida, Hideto
Kano, Kenji
Ikeda, Tokuji
Nagasawa, Toru
Ueda, Teruhisa
Nicotinic acid (NA) is efficiently hydroxylated into 6-hydroxynicotinic acid (6HNA) by Pseudomonas fluorescens TN5-immobilized column electrolytic method using K3Fe(CN)6 as an extracellular electron transfer mediator, in which the conversion rate was sufficiently accelerated compared with the aerobic oxidation. The NA conversion system was applied to the continuous-production of 6HNA in 100% yield and the absolute determination of NA in flow-injection analysis.
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