An uridine derivative containing a hydrophobic fluorescent probe at the 2'-position: Synthesis and its incorporation into oligonucleotides

Article abstract of DOI:10.1016/S0040-4039(97)01329-4

The synthesis of 2'-(6-dimethylamino-2-naphthamide)uridine [U(DAN)] has been described. The nucleoside was converted to the 5'-dimethoxytrityl nucleoside phosphoramidite which could be used for incorporation of U(DAN) into the desired positions of the oligonucleotide sequence.