Arylation of 1,3-dimethyllumazines by arenediazonium salts

Article abstract of DOI:10.3987/COM-97-7748

Reaction of 7-methoxy-l,3-dimethyllumazine with benzenediazonium chloride in an alkaline aqueous solution afforded 6-phenyl- and 6-biphenyl-7-methoxy-l,3-dimethyllumazines. Treatment of 7-dimethylamino-l,3-dimethyllumazine with benzenediazonium chloride similarly gave the 6-phenyl and 6-biphenyl derivatives of the substrate together with 7-methylamino-6-phenyl-1,3-dimethyllumazine. Analogous reactions of 7-substituted 1,3-dimethyllumazines with several arenediazonium chlorides are described.