Kinetic Study on the γ-Radiolysis of 5-Fluorouracil Derivatives

Article abstract of DOI:10.1246/cl.1989.707

The reactivity of 5-fluoro-1-(2-phenylethenesulfonyl)uracil (1) and 5-fluoro-1-phenylthioureidouracil (2) in the γ-radiolysis of their aqueous solutions was studied by a competitive kinetic method using nitrobenzene and acetone as reference compounds.The rate constants for the reactions of 1 and 2 with e_aq^- were of the same order of magnitude as that for nitrobenzene.The efficiencies of the conversion of intermediates generated from 1 and 2 into 5-fluorouracil were also estimated.