Biological and Pharmaceutical Bulletin p. 935 - 938 (1997)
Update date:2022-08-11
Topics:
Hamada, Akinobu
Nakano, Masahiro
Shimidzu, Satoshi
Hasegawa, Tetsuya
Kawaguchi, Takeo
The inhibitory effect of acyclothymidine[AcyT, 5-methyl-1-(2'- hydroxyethoxymethyl) uracil], a potent pyrimidine nucleoside phosphorylase (PyNPase) inhibitor, on 5'-deoxy-5-fluorouridine (5'-DFUR) phosphorolysis in human and mouse tumor cell homogenates was measured. Competitive inhibition was observed in MKN-74 and Lewis lung carcinoma (LLC), whereas non- competitive inhibition was observed in HeLa. The strength of the inhibitory effect by AcyT showed the following pattern: HeLa
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