5-Bromobarbituric acid : A mild and selective monobrominating agent employed in the synthesis of the gastrin antagonist GR174152

Article abstract of DOI:10.1080/00397919608004658

5-Bromobarbituric acid (5) is a convenient reagent for the selective bromination of cyclic imine 3. A facile, in situ synthesis of this reagent involving a disproportionation reaction between barbituric acid and dibromobarbituric acid is described.

Full text of DOI:10.1080/00397919608004658

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Synthetic Communications: An
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5-Bromobarbituric Acid : A Mild
and Selective Monobrominating
Agent Employed in the
Synthesis of the Gastrin
Antagonist GR174152
Robert Bright a , Steven J. Coote a , Stephen
Freeman a , Doug Hayes a , Gordon Smith a & David
Tapolczay a
a Process Research Department , Glaxo Wellcome
Medicines Research Centre , Gunnels Wood Road
STEVENAGE, Herts SG1 2NY
Published online: 19 Aug 2006.
To cite this article: Robert Bright , Steven J. Coote , Stephen Freeman , Doug
Hayes , Gordon Smith & David Tapolczay (1996) 5-Bromobarbituric Acid : A Mild
and Selective Monobrominating Agent Employed in the Synthesis of the Gastrin
Antagonist GR174152, Synthetic Communications: An International Journal for
Rapid Communication of Synthetic Organic Chemistry, 26:22, 4195-4209, DOI:
10.1080/00397919608004658
To link to this article: http://dx.doi.org/10.1080/00397919608004658
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