Efficient 1,3 ester shift in α-disubstituted β-ketoester enolates. Remarkable influence of the metal counterion on the rate of reaction

Article abstract of DOI:10.1016/S0040-4039(00)73342-9

The efficient and rapid α to γ rearrangement of the carbalkoxy group in α-disubstituted β-ketoesters is reported. The reaction proceeds at room temperature and in high yields when performed under naked anion conditions. A crossover experiment using approp