Bioorganic and Medicinal Chemistry Letters p. 587 - 592 (1998)
Update date:2022-08-18
Topics:
Anufriev, Victor Ph.
Novikov, Vyacheslav L.
Maximov, Oleg B.
Elyakov, George B.
Levitsky, Dmitry O.
Lebedev, Alexander V.
Sadretdinov, Safa M.
Shvilkin, Alexei V.
Afonskaya, Natalya I.
Ruda, Mikhail Ya.
Cherpachenko, Nina M.
A series of hydroxynaphthazarins has been synthesized. Some of them were found in in vivo experiments to be protectors of myocardium under ischemia-reperfusion and to reduce the infarction zone by 50% without any adverse effect. All compounds exhibit a moderate or small toxicity and are active in low doses.
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