Synthesis of some hydroxynaphthazarins and their cardioprotective effects under ischemia-reperfusion in vivo

Article abstract of DOI:10.1016/S0960-894X(98)00075-4

A series of hydroxynaphthazarins has been synthesized. Some of them were found in in vivo experiments to be protectors of myocardium under ischemia-reperfusion and to reduce the infarction zone by 50% without any adverse effect. All compounds exhibit a moderate or small toxicity and are active in low doses.