Bioorganic and Medicinal Chemistry Letters p. 647 - 652 (1999)
Update date:2022-08-29
Topics:
Zarrinmayeh, Hamideh
Zimmerman, Dennis M.
Cantrell, Buddy E.
Schober, Douglas A.
Bruns, Robert F.
Gackenheimer, Susan L.
Ornstein, Paul L.
Hipskind, Philip A.
Britton, Thomas C.
Gehlert, Donald R.
A series of benzimidazoles (4) was synthesized and evaluated in vitro as potent and selective NPY Y1 receptor antagonists. Substitution of the piperidine nitrogen of 4 with appropriate R groups resulted in compounds with more than 80-fold higher affinity
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(1985)Doi:10.1016/S0040-4039(00)00647-X
(2000)Doi:10.1016/S0031-9422(82)85080-2
(1982)Doi:10.1063/1.439686
(1980)Doi:10.1021/acs.jafc.9b07689
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