Chemistry of Heterocyclic Compounds p. 1265 - 1270 (1988)
Update date:2022-08-16
Topics:
Bulychev, Yu. N.
Preobrazhenskaya, M. N.
The alkylation of allopurinol and inosine with dimethylformamide (DMF) dimethylacetal or diethylacetal was studied.Allopurinol is alkylated in both the pyrazole and pyrimidine rings. 1,5- and 2,5-Dimethyl derivatives are formed in the case of methylation. 1,5- and 2,5-Diethylderivatives, as well as 1-ethyl-4-ethoxypyrazolo<3,4-d>pyrimidine, were obtained in the ethylation of allopurinol.The yields of the 1,5-substitued compounds are highest in both cases.The alkylation of inosine with DMF diethylacetal takes place in the 1 and 6 positions.
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