ALKYLATION OF ALLOPURINOL AND INOSINE WITH DIMETHYLFORMAMIDE DIMETHYLACETAL OR DIETHYLACETAL

Article abstract of DOI:10.1007/BF00633508

The alkylation of allopurinol and inosine with dimethylformamide (DMF) dimethylacetal or diethylacetal was studied.Allopurinol is alkylated in both the pyrazole and pyrimidine rings. 1,5- and 2,5-Dimethyl derivatives are formed in the case of methylation. 1,5- and 2,5-Diethylderivatives, as well as 1-ethyl-4-ethoxypyrazolo<3,4-d>pyrimidine, were obtained in the ethylation of allopurinol.The yields of the 1,5-substitued compounds are highest in both cases.The alkylation of inosine with DMF diethylacetal takes place in the 1 and 6 positions.