Tetrahedron Letters p. 1631 - 1634 (1999)
Update date:2022-08-25
Topics:
Han, Luning
Razdan, Raj K.
Total synthesis of 2-Arachidonylglycerol (2-Ara-Gl) was accomplished starting from arachidonic acid and glycerol. The sequence involves selective protection of the primary alcohols of glycerol, esterification, and mild hydrolysis of the protecting groups. A unique hydrolysis condition was developed to prevent isomerization of the 2-Ara-Gl to the more stable 1- monoglyceride.
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