Novel reduction and hydroxylation products formed by Aspergillus fumigatus from Reichstein's Substance S

Article abstract of DOI:10.1016/S0039-128X(96)00205-X

Fermentation of Reichstein's Substance S with Aspergillus fumigatus (AM- 21) under aerobic conditions yielded 17α, 21-dihydroxy-5α-pregn-1-ene- 3,20-dione, 17α,20α,21-trihydroxy-5α-pregn-1-en-3-one, 6β,17α,21- trihydroxypregn-4-en-3,20-dione, 15β,17α,21-trihydroxy-5α-pregnane-3,20- dione, and 15β,17α,20α,21-tetrahydroxy-5α-pregn-1-en-3-one. Each microbial metabolite was characterized by spectroscopic methods, including ¹³C NMR chemical shifts.