Preparation of zinc organometallics derived from nucleosides and nucleic acid bases and Pd(0) catalyzed coupling with aryl iodides

Article abstract of DOI:10.1016/0040-4039(96)01934-X

5-Iodouracil and 6-iodopurine derivatives readily insert zinc dust (25°C or 70°C) in THF or DMAC affording zincated nucleic acid base derivatives which undergo efficient palladium catalyzed cross-coupling reactions with aryl iodides in good yields. This r