Advanced Synthesis and Catalysis p. 2547 - 2555 (2015)
Update date:2022-08-11
Topics:
Nemoto, Tetsuhiro
Yamaguchi, Mami
Kakugawa, Kazumi
Harada, Shingo
Hamada, Yasumasa
Gephyrotoxin 287C, a bioactive alkaloid bearing a perhydropyrrolo[1,2-a]quinoline skeleton with five stereocenters, is an attractive target for synthetic organic chemistry. We achieved an enantioselective total synthesis of (+)-gephyrotoxin 287C, for which the key steps were palladium-catalyzed asymmetric allylic amination using a chiral diaminophosphine oxide (DIAPHOX) preligand, diastereoselective intramolecular Mannich reaction, and tin tetrachloride-catalyzed diastereoselective conjugate addition/protonation.
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Doi:10.1021/acs.biochem.8b00031
(2018)Doi:10.1016/S0040-4039(02)01461-2
(2002)Doi:10.1002/ejoc.201500322
(2015)Doi:10.1016/S0040-4039(00)84727-9
(1986)Doi:10.1021/acs.analchem.8b02799
(2018)Doi:10.1016/j.bmc.2003.11.003
(2004)
