Extending mechanochemical porphyrin synthesis to bulkier aromatics: Tetramesitylporphyrin

Article abstract of DOI:10.3762/bjoc.15.111

Aldehydes with bulky substituents in the ortho-positions have been historically difficult in porphyrin synthesis, presumably owing to steric hindrance around the reactive site. We have used mechanochemistry for the simple, room-temperature synthesis of te