An improved preparation of aromatase inhibitor 4-hydroxyandrost-4-ene-3,17-dione

Article abstract of DOI:10.1080/00397919208021325

The title compound has been prepared in 47% overall yield from androst-4-ene-3,17-dione (1) by a two-step sequence comprising hydroxylation of 1 with OsO₄/H₂O₂, followed by dehydration of the resultant diols 3 in alkaline medium.

Full text of DOI:10.1080/00397919208021325

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Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic
Organic Chemistry
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An Improved Preparation
of Aromatase Inhibitor 4-
Hydroxyandrost-4-ene-3,17-
dione
a
a
Pier Giuseppe Ciattini , Enrico Morera & Giorgio
a
Ortar
a
Dipartimento di Studi Farmaceutici e Centro di
Studio per la Chimica del Farmaco del C.N.R. ,
Università ‘La Sapienza’ , 00185, Roma, Italy
Published online: 23 Sep 2006.
To cite this article: Pier Giuseppe Ciattini , Enrico Morera & Giorgio Ortar (1992) An
Improved Preparation of Aromatase Inhibitor 4-Hydroxyandrost-4-ene-3,17-dione,
Synthetic Communications: An International Journal for Rapid Communication of
Synthetic Organic Chemistry, 22:13, 1949-1952
To link to this article: http://dx.doi.org/10.1080/00397919208021325
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