Synthesis of secondary carbinamine via n-boryl imines generated from nitriles and alkylboranes

Article abstract of DOI:10.1016/S0040-4039(00)92328-1

The partial reduction of nitriles with several alkylboranes produced an addition product, N-boryl imine, which was readily converted to secondary carbinamine by treatment with organolithium or Grignard reagents. Optically active N-boryl imines were also prepared from chiral borane and nitrile for the chiral amine synthesis.