Exploiting the S4-S5 Specificity of Human Neutrophil Proteinase 3 to Improve the Potency of Peptidyl Di(chlorophenyl)-phosphonate Ester Inhibitors: A Kinetic and Molecular Modeling Analysis

DOI: 10.1021/acs.jmedchem.7b01416

Source and publish data:

Journal of Medicinal Chemistry p. 1858 - 1870 (2018)

Update date:2022-08-10

Topics:

Authors:

Guarino, Carla

Gruba, Natalia

Grzywa, Renata

Dyguda-Kazimierowicz, Edyta

Hamon, Yveline

??gowska, Monika

Skoreński, Marcin

Dallet-Choisy, Sandrine

Marchand-Adam, Sylvain

Kellenberger, Christine

Jenne, Dieter E.

Sieńczyk, Marcin

Lesner, Adam

Gauthier, Francis

Korkmaz, Brice

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/acs.jmedchem.7b01416

The neutrophilic serine protease proteinase 3 (PR3) is involved in inflammation and immune response and thus appears as a therapeutic target for a variety of infectious and inflammatory diseases. Here we combined kinetic and molecular docking studies to i

Full text of DOI:10.1021/acs.jmedchem.7b01416

Products guided by the article

Product name:tris(4-chlorophenyl) phosphite

Cas No:5679-61-8

R&D Labs maybe for 5679-61-8

Xiamen XM-Innovation Chemical Co., Ltd

Contact:+86-592-3216205

Address:Unit Q, 11/F, No.1 Office Building, Wuyuan Bay Business Center, Huli District, Xiamen City, Fujian Province, P.R.C
shanghai jiuling chemical co.,ltd.

Contact:+86-21-50387295

Address:Zaozhuang Road, Pudong, Shanghai City. China
Guangzhou Shiny Co., Ltd.

Contact:+86-20-62802632;62802633

Address:Room 330 GIGCAS Building,No.511 Kehua Street,Tianhe District
Greenutra Resource Inc

website:http://www.greenutra.cn

Contact:0086-411-39553357

Address:No. 7-1-1802, Huizhi Garden,Ocean Square,Dalian, 116033, China
Nantong Chem-land Co., Ltd.

Contact:86 513 85512619

Address:Rm.1306, Building A, Wenfeng Mansion,168 Gongnong Road, Nantong Jiangsu China

Relevant to this article

Doi:10.1021/ja01084a019
(1965)
ArF laser photolytic deposition and thermal modification of an ultrafine chlorohydrocarbon

Doi:10.2478/s11696-010-0048-0
(2010)
Synthesis and solution behavior of the trinuclear palladium(II) unsaturated carboxylate complexes triangle-Pd₃[μ-O₂CC(R′) = CHMe]₆ (R′ = Me, H): X-ray structure of palladium(II) tiglate (R′ = Me)

Doi:10.1016/j.ica.2007.05.058
(2007)
Biosynthesis of 3-amino-5-hydroxybenzoic acid, the precursor of mC₇N units in ansamycin antibiotics

Doi:10.1021/ja9601292
(1996)
Doi:10.1021/ja00864a050
(1962)
Reactions of aniline in acetic acid solutions containing cyanuric chloride and hydrogen chloride acceptors

Doi:10.1139/V07-129
(2007)

Article Doi